Synthetic Route of 550347-54-1 ,Some common heterocyclic compound, 550347-54-1, molecular formula is C6H5ClIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a stirred solution of 2-chloro-5-iodo-4-methyl-pyridine (23. Og, 90.909mmol, 1 eq) in 1 ,2-dichloroethane (230ml_) was added NBS (24.3g, 136mmol, 1 .5eq) followed by addition of AIBN (6.0g, 36.4mmol, 0.4eq) at room temperature in dark. Resulting reaction mixture was heated at 80C for 16 hours. After maximum consumption of starting material, reaction mixture was cooled to room temperature and quenched with water (50ml_), extracted with DCM (3x50ml_). Combined organic phase was washed with brine (50ml_), dried over anhydrous Na2S04 and concentrated under reduced pressure to get dark brown semi solid (20g, crude). Crude of title compound was used as such for next reaction. LC-MS (m/z): No ionisation.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 550347-54-1, 2-Chloro-5-iodo-4-methylpyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ZOETIS LLC; MENON, Sanjay; SHEEHAN, Susan M.K.; VAILLIANCOURT, Valerie A.; WO2014/39484; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem