Analyzing the synthesis route of 2-Amino-4-ethoxypyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52311-20-3, 2-Amino-4-ethoxypyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 52311-20-3, 2-Amino-4-ethoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-4-ethoxypyridine, blongs to pyridine-derivatives compound. Safety of 2-Amino-4-ethoxypyridine

4-Ethoxy-pyridin-2-ylamine (15 g, 109 mmol) is dissolved in HOAc (100 mL) and cooled to 0 C. Bromine is added dropwise with vigorous stirring. The mixture is allowed to stir at RT for 30 minutes at which point a precipitate forms. The mixture is stirred for 30 min and the solids collected by filtration, washed with EtOAc in dried in a vacuum oven to give 5-bromo-4-ethoxy-pyridin-2-ylamine hydrobromide (23.3 g, 78.2 mmol).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52311-20-3, 2-Amino-4-ethoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; Boehringer Ingelheim International GmbH; LIU, Pingrong; MILLER, Craig Andrew; YU, Maolin; ZHANG, Zhonghua; (93 pag.)US2018/72717; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem