The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1256811-02-5, name is 1-(5-Bromo-2-methoxypyridin-3-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H8BrNO2
Step 4-Synthesis of 2-bromo-1-(5-bromo-2-hydroxypyridin-3-yl)ethanone To a solution of 1-(5-bromo-2-methoxypyridin-3-yl)ethanone (2.0 g, 8.69 mmol) in HBr (20 mL, HOAc solution), Br2 (1.4 g, 8.76 mmol) was added dropwise at room temperature. The reaction mixture was stirred at room temperature for 5 hours. Then the reaction mixture was filtered to collect the HBr salt. The solid was suspended with Na2CO3 solution, extracted with EtOAc. The combined organic phases were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo to provide 2-bromo-1-(5-bromo-2-hydroxypyridin-3-yl)ethanone (2.0 g, yield: 74%). 1H-NMR (DMSO, 400 MHz) delta 12.83 (br s, 1H), 8.11?8.13 (m, 2H), 4.85 (s, 2H). MS (M+H)+: 295.
With the rapid development of chemical substances, we look forward to future research findings about 1256811-02-5.
Reference:
Patent; Liverton, Nigel J.; McComas, Casey Cameron; Habermann, Joerg; Koch, Uwe; Narjes, Frank; Li, Peng; Peng, Xuanjia; Soll, Richard; Wu, Hao; Palani, Anandan; He, Shuwen; Dai, Xing; Liu, Hong; Lai, Zhong; London, Clare; Xiao, Dong; Zorn, Nicolas; Nargund, Ravi; US2014/213571; (2014); A1;,
Pyridine – Wikipedia,
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