A new synthetic route of 139585-48-1

With the rapid development of chemical substances, we look forward to future research findings about 139585-48-1.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 139585-48-1, name is 2-Chloro-5-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H6ClNO

Carboxylic acid XIIIAcid XIII-I5 ‘-Methoxy-3,4,5,6-tetrahydro-2H- [ 1 ,2 ‘] bipyridinyl-4-carboxylic acida) 5′-Methoxy-3,4,5,6-tetrahydro-2H-[l,2’]bipyridinyl-4-carboxylic acid ethyl esterTo a stirred solution of piperidine-4-carboxylic acid ethyl ester (0.52 g, 3.34 mmol) and 2- chloro-5-methoxy-pyridine in 10 mL of toluene was added (13 mg, 0.057 mmol) of Pd(II) acetate, (17 mg, 0.027 mmol) of BINAP and tBuOK (0.44 g, 3.90 mmol). The mixture was heated at 1200C for two hours, concentrated under vacuo and the residue was directly purified on column chromatography (SiO2, EtOAc/Hept 1 :2) yielding 0.17 g (24 %) of the title compound as a light yellow oil. ES-MS m/e: 265.3 (M+H+).

With the rapid development of chemical substances, we look forward to future research findings about 139585-48-1.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; JABLONSKI, Philippe; KNUST, Henner; NETTEKOVEN, Matthias; PATINY-ADAM, Angelique; RATNI, Hasane; RIEMER, Claus; WO2011/23626; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem