Related Products of 167837-43-6, Adding some certain compound to certain chemical reactions, such as: 167837-43-6, name is (E)-3-(6-Aminopyridin-3-yl)acrylic acid,molecular formula is C8H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 167837-43-6.
e) 3-(6-amino-pyridin-3-yl)-N-(3-cyano-lH-indol-2-yhnethyl)-N-methyl-acrylamide; EDC (250 mg, 1.3 mmol) was added to a solution of (£)-3-(6-Amino-pyridin-3-yl)- acrylic acid (172 mg, 1.05 mmol), 2-methylaminomethyl-lH-indole-3-carbonitrile (186 mg, 1.0 mmol), HOBf H2O (135 mg, 1.0 mmol) and DPEA (510 muL, 3.0 mmol) in dry DMF (4 mL). After 3 days of stirring, the mixture was diluted with water (50 mL) at 100C. The resulting precipitate was filtered, washed with water and dried to afford the title compound (277 mg, 84%). 1H NMR (300 MHz, DMSO-d6, delta): 12.1 (m, IH), 8.16 (s, IH), 7.84 (s, IH), 7.5 (m, 3H), 7.2 (m, 2H), 6.97 (m, IH), 6.44 (s, 2H), 5.08 and 4.88 (rotamers, 2s, 2H), 3.22 and 2.96 (rotamers, 2s, 3H). MS (ESI): m/e 332 (M+H)+.
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Reference:
Patent; AFFINIUM PHARMACEUTICALS, INC.; WO2007/53131; (2007); A2;,
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