As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 80862-08-4, name is 6-Methoxy-1H-pyrrolo[3,2-c]pyridine, molecular formula is C8H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 6-Methoxy-1H-pyrrolo[3,2-c]pyridine
Allylpalladium(ll) chloride dimer (558 mg, 1.52 mmol) and triphenylphosphine (1.75 g, 6.68 mmol) were dissolved in dry DMF (210 ml) and stirred at room temperature for 30 min. Carbonic acid cyclohex-2-enyl ester methyl ester (9.47 g, 60.74 mmol) was added and the mixture stirred for additional 30 min. 6-Methoxy-1 H-pyrrolo[3,2- c]pyridine (4.5 g, 30.37 mmol) and cesium carbonate (19.79 g, 60.74 mmol) were added, and the reaction mixture was stirred at room temperature for 16 h. Then the mixture was partitioned between water and EA, the aqueous phase extracted with EA and the combined organic phases dried over sodium sulfate and concentrated. The residue was purified by silica gel column chromatography (EA/HEP) to give 5.6 g of the title compound. LC/MS (method LC4): m/z = 229
With the rapid development of chemical substances, we look forward to future research findings about 80862-08-4.
Reference:
Patent; SANOFI-AVENTIS; WO2009/95162; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem