Adding a certain compound to certain chemical reactions, such as: 867279-13-8, 4-Bromo-2-chloro-5-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Bromo-2-chloro-5-methylpyridine, blongs to pyridine-derivatives compound. Safety of 4-Bromo-2-chloro-5-methylpyridine
Step 3: To a solution 4-bromo-2-chloro-5-methylpyridine (75 g, 363 mmol) in THF (500 mL) was added isopropylmagnesium chloride lithium chloride (1397 mL of 1.3M solution in THF,1816 mmol) at 0 C, The resulting mixture stirred at 22 C for 1 h. Then, the resulting mixture was stirred at 22 C under CO2 (1 atm) for 40 mm. The mixture was quenched with H20 (1500 mL) and extracted with EtOAc (300 mL x 2). The aqueous phase was adjusted to pH 5 withM aqueous HC1 and then was extracted with EtOAc (300 mL x 3). The resulting organic layers were washed with brine (300 mL) and concentrated in vacuum to give 2-chloro-5-methylisonicotinic acid as a light yellow solid, which was used directly in next step without further purification. MS: 172 (M + 1). ?H NMR (400 MHz, DMSO-d6) 8.39 (s, 1H), 7.68 (s, 1H), 2.43 (s, 3H).
The synthetic route of 867279-13-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CTXT PTY. LTD.; MACHACEK, Michelle, R.; WITTER, David, J.; REUTERSHAN, Michael Hale; ALTMAN, Michael, D.; STUPPLE, Paul Anthony; (67 pag.)WO2019/94311; (2019); A1;,
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