A common compound: 18368-63-3, name is 2-Chloro-6-methylpyridine,molecular formula is C6H6ClN, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 18368-63-3
A mixture of 2-chloro-6-methylpyridine 3e (1.30 g, 10.2 mmol), potassium carbonate (2.12 g, 15.3 mmol) and benzyl mercaptane (1.90 g, 15.3 mmol) in DMSO (10 mL) was stirred at 150 C for 3 h. After cooled to room temperature, H2O was added and extracted with EtOAc. The extract was washed with a solution of NaHCO3, H2O and brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (n-hexane/EtOAc = 15/1) to afford compound 4e (1.90 g, 87%) as a colorless oil: 1H-NMR (CDCl3) d 2.52 (3H, s), 4.41 (2H, s), 6.81-6.83 (1H, m), 6.93-6.95 (1H, m), 7.20-7.42 (6H, m).
With the rapid development of chemical substances, we look forward to future research findings about 18368-63-3.
Reference:
Article; Nishida, Haruyuki; Fujimori, Ikuo; Arikawa, Yasuyoshi; Hirase, Keizo; Ono, Koji; Nakai, Kazuo; Inatomi, Nobuhiro; Hori, Yasunobu; Matsukawa, Jun; Fujioka, Yasushi; Imanishi, Akio; Fukui, Hideo; Itoh, Fumio; Bioorganic and Medicinal Chemistry; vol. 25; 13; (2017); p. 3447 – 3460;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem