Electric Literature of 1160791-13-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1160791-13-8, name is 2-Amino-6-bromothiazolo[5,4-b]pyridine, molecular formula is C6H4BrN3S, molecular weight is 230.09, as common compound, the synthetic route is as follows.
Step 2: l-allyl-3- (6-bromothiazolo [5,4-b] pyridin-2-yl) urea (Intermediates). In a 25 ml round-bottomed flask, 6-bromothiazolo [5,4-b] pyridin-2-amine (0.575 g, 2.5 mmol) was suspended in tetrahydrofuran (15 mL). To this triethylamine (0.697 mL,5.00 mmol) was added in one portion and resulting reaction mixture was stirred at RT.Then allyl isocyanate (0.331 mL, 3.75 mmol) was added and stirred at RT for overnight.The reaction mixture was evaporated in vacuo, ice-cold water was added, sonicated well and the precipitated solid was filtered and dried under high vacuum. The crude product was triturated with acetonitrile gave the pure product as brown solid (0.650mg, 83%).MS (ES+): 314 for C10H9BrN4OS1H NMR (DMSO-d6) delta: 3.82 (t, 2H,CH2); 5.10 -5.25(m, 2H,CH2); 5.80 -5.95(m,IH5CH); 6.95 (t, IH5NH); 8.15 (bs, IH5NH); 8.23 (s, lH,Aro.); 8.48 (s, lH,Aro.).
The chemical industry reduces the impact on the environment during synthesis 1160791-13-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/147431; (2009); A1;,
Pyridine – Wikipedia,
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