The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1121-60-4, name is Picolinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. 1121-60-4
The 2-pyridine benzaldehyde (10.7g, 0.1mol),Malonic acid (25.5g, 0.25mol) was added to a 100ml round bottom flask,Add 30ml of pyridine as a solvent and stir it magnetically. After all of it is dissolved,Inject 1.6g piperidine into the system, warm the oil bath to 65 C, and react for 3h.Follow the reaction by thin layer chromatography. After the reaction is complete, cool the reaction solution to 0-5 C .Poured into a mixture of ice and water containing concentrated hydrochloric acid (12mol / l, 50ml), a large amount of white solid was precipitated and filtered with suction to obtain the desired 2-pyridineacrylic acid in a molar yield of 78%.
Statistics shows that 1121-60-4 is playing an increasingly important role. we look forward to future research findings about Picolinaldehyde.
Reference:
Patent; Changzhou Chuanyou Environmental Protection Technology Co., Ltd.; Ni Jun; (4 pag.)CN110746346; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem