Simple exploration of 609-71-2

The chemical industry reduces the impact on the environment during synthesis 609-71-2, I believe this compound will play a more active role in future production and life.

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 609-71-2 as follows., 609-71-2

A stirred solution of substituted anilines (1.0 mmol) in CH2Cl2 (5 mL) was treated with equimolar quantities of substituted nicotinic acids, using EDC.HCl (0.216 g, 1.2 mmol) as condensing agent. The mixture was refluxed for 8-10 h. Flash chromatography (MeOH/CH3Cl, 1:10) afforded the corresponding compound as white powder.

The chemical industry reduces the impact on the environment during synthesis 609-71-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Shi, Lei; Li, Zi-Lin; Yang, Ying; Zhu, Zhen-Wei; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry Letters; vol. 21; 1; (2011); p. 121 – 124;,
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