Synthetic Route of 863878-22-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 863878-22-2, name is 6-Chloro-4-methyl-3-nitropyridin-2-amine. A new synthetic method of this compound is introduced below.
Step 1 : (‘/?/)-(1-(6-Amino-4-methyl-5-nitropyridin-2-yl)piperidin-3-yl)(pyrrolidin-1 – yl)methanone (‘/?/)-(1 -(6-Amino-4-methyl-5-nitropyridin-2-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone was prepared using a method analogous to the one used for Intermediate 2, Step 1 but using 6-chloro-4-methyl-3-nitropyridin-2-amine and (7?,)-piperidin-3-yl(pyrrolidin-1 – yl)methanone as starting materials. The reaction mixture was run at 70C for 1 h. MS (ES+APCI) (M+H) 333.9; LCMS retention time 4.322 min (Method Z).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,863878-22-2, 6-Chloro-4-methyl-3-nitropyridin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER INC.; AHN, Kay; BOEHM, Markus; CABRAL, Shawn; CARPINO, Philip A.; FUTATSUGI, Kentaro; HEPWORTH, David; KUNG, Daniel W.; ORR, Suvi; WANG, Jian; WO2013/150416; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem