Related Products of 60186-15-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60186-15-4, name is 2,4-Difluoro-5-nitropyridine. A new synthetic method of this compound is introduced below.
In a 250 mL round-bottomed flask vial was 2,4-difluoro-5-nitropyridine (1.035 g, 6.47 mmol) in tetrahydrofuran (30 mL) to give a tan solution. After cooling to -40 C, 1 -allylpiperazine (0.905 mL, 6.47 mmol) was added, followed by Et3N (1.802 mL, 12.93 mmol). The cloudy tan mixture was stirred at -40 C – -10C for 3 h. TLC (1/1 EtOAc/hexane) showed one major more polar yellow spot. The mixture was concentrated, and the residue was purified by FCC up to 80% EtOAc/hexane to afford the desired product (1.4347 g, 83%) as a yellow solid: 1H NMR (0112) (400 MHz, Chloroform-d) delta 8.58 (s, 1H), 6.41 (s, 1H), 5.97 – 5.77 (m, 1H), 5.31 – 5.1 (m, 2H), 3.33 – 3.23 (m, 4H), 3.09 (dt, J = 6.7, 1.3 Hz, 2H), 2.68 – 2.58 (m, 4H); 19F NMR (376 MHz, Chloroform-d) delta -62.07.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60186-15-4, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; SIVAPRAKASAM, Prasanna; DUBOWCHIK, Gene M.; MACOR, John E.; (45 pag.)WO2018/98413; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem