Related Products of 52311-50-9, Adding some certain compound to certain chemical reactions, such as: 52311-50-9, name is 2-Chloro-4-ethoxypyridine,molecular formula is C7H8ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52311-50-9.
Solid 2-chloro-4-ethoxypyridine (100 g 0.63 mol) was added to H2SO4(500 mL) slowly. Then 1-bromopyrrolidine-2 5-dione (124.2 g 0.70 mol) was added into above mixture at rt. The mixture was stirred at 80 for 3 h. TLC (PE/EA 101 Rf 0.5) showed the reaction was finished. The reaction mixture was poured into ice-water (2 L) and extracted with EA (1 L x 3) . The organic layer was washed with saturated Na2CO3solution (1 L x 2) dried over Na2SO4and concentrated. The residue was purified on silica column chromatography (PE/EA 601-301) . All fractions found to contain product by TLC (PE/EA 101 Rf 0.5) were combined and concentrated to yield 5-bromo-2-chloro-4-ethoxypyridine (60.9 g 0.26 mol 40yield) 1HNMR(400 MHz CD3OD) delta 8.31 (s 1H) 7.14 (s 1H) 4.32-4.10 (m 2H) 1.58-1.35 (m 3H) ES-LCMS m/z 237 (M+2)
According to the analysis of related databases, 52311-50-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem