19524-06-2, Adding a certain compound to certain chemical reactions, such as: 19524-06-2, 4-Bromopyridine hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 19524-06-2, blongs to pyridine-derivatives compound.
To a solution of 4-bromopyridine hydrochloride (8.9 g, 45.77 mmol) in dioxane (100 mL) and H20 (12.5 mL) was added cyclopropylboronic acid (5.8 g, 68.1 mmol), Pd(dppf)Cl2 (2.0 g, 2.75 mmol) and potassium phosphate (27.9 g, 131.8 mmol) under N2. The mixture was stirred at 90 C for 16 h. Water (100 mL) was added, filtered and the residue was extracted with EtOAc (100 mLx3), dried over Na2S04, filtered and concentrated in vacuum. To the residue was added HCl (5 mol/L, 50 mL), extracted with DCM (50 mL x3), the aqueous layer was basified with NaOH (5 mol/L, 100 mL) and extracted with DCM (50 mL x4), dried over Na2S04, filtered and concentrated in vacuum to afford 4-cyclopropylpyridine (4.1 g, 27.0 mmol, 59 % yield) as a black oil. MS (ES+) C8H9N requires: 119, found 120 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19524-06-2, its application will become more common.
Reference:
Patent; TESARO, INC.; LEWIS, Richard T.; JONES, Philip; PETROCCHI, Alessia; REYNA, Naphtali; HAMILTON, Matthew; CROSS, Jason; TREMBLAY, Martin; LEONARD, Paul Graham; (216 pag.)WO2018/136887; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem