New downstream synthetic route of 571188-59-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound,571188-59-5, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. 571188-59-5

900 mg of Compound 5 was dissolved in 10 mL of toluene solution. Add 4 mL of 1 mol/L LiHMDS at 0~10 CA solution of tetrahydrofuran was stirred for 1 h. Add 450 mg of compound 1 in toluene at 0~10 C and slowly return to room temperature.2.5h. After the end of the HPLC monitoring reaction, the reaction was quenched with 9 mL of saturated ammonium chloride, and the organic phase was separated, using anhydrous sulfuric acid.The sodium was dried, and the filtrate was collected by filtration.86%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,571188-59-5, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Suzhou Pengxu Pharmaceutical Technology Co., Ltd.; Li Pixu; Wang Peng; Wei Qiang; (7 pag.)CN109553621; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem