Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1401624-81-4, name is 2,6-Dibromo-[1,2,4]triazolo[1,5-a]pyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 2,6-Dibromo-[1,2,4]triazolo[1,5-a]pyridine
General procedure: d) 6-Bromo-2-morpholin-4-yl-[ 1 ,2,4] triazolo[ 1 ,5-a]pyridine A mixture of 2,6-dibromo-[l,2,4]triazolo[l,5-a]pyridine (1 g, 3.61 mmol) and morpho- line (10 g, 10 ml, 115 mmol) was refluxed for 4 hours under argon atmosphere. The mixture was evaporated to dryness under reduced pressure. Flash chromatography (silica gel, 50 g, 30-100% heptane/ethyl acetate) afforded 6-bromo-2-morpholin-4-yl-[l,2,4]triazolo[l,5-a]pyridine (672 mg, 66%) as a light yellow solid. Mp.: 136C. MS: m/z=283.0/285.0 (M+H+).
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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; WO2013/41472; (2013); A1;,
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