The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 72093-04-0, name is 3-Chloro-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H6ClN
To a mixture of 2-amino-N,N-dimethylbenzamide (1.3 g, 6.77 mmol), 3-chloro-4-methylpyridine (0.745 mL, 6.77 mmol), Palladium acetate (0.150 g) and BINAP (0.60 g) in 1,4-dioxane (10 mL) was added NaH (0.677 g, 16.93 mmol) and the resulting mixture was heated at 100 C. for 2 hours. The solvent was removed under reduced pressure. The residue obtained was taken into dichloromethane (50 mL) and filtered through celite. The filtrate was washed with water (50 mL), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified using flash column chromatography (SiO2) to provide 0.450 g of the desired product as a dark oil.
With the rapid development of chemical substances, we look forward to future research findings about 72093-04-0.
Reference:
Patent; ArQule, Inc.; US2010/249108; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem