Reference of 73112-16-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 73112-16-0, name is 2,6-Dibromo-4-methylpyridine, molecular formula is C6H5Br2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2,6-Dibromo-4-methylpyridine (3.76 g, 14.98 mmol) in dichloromethane (DCM) (80 mL) was added.Cool to -78 C. under nitrogen.While maintaining the internal temperature below -70 C,n-Butyllithium (2.5 M in hexane) (6.59 mL, 16.48 mmol) was added dropwise.After the addition is completeThe solution becomes a suspensionStir at -78 C. for 15 minutes.While keeping the internal temperature below -60 C,A solution of dihydrofuran-3 (2H) -one (1.548 g, 17.98 mmol) in 2 mL of DCM was added over 3 minutes.After the addition is completeReduce the temperature back to -78 C,Stir for 30 minutes.The product with saturated aqueous NH4Cl,Extracted with DCM.The organic portion was dried over MgSO 4, filtered and concentrated to give a residue that was purified on a silica gel column eluted with 0-50% ethyl acetate / heptane to give the product (2.13 g, yield). 55%).
According to the analysis of related databases, 73112-16-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Abbvie Incorporated; Argiriadi, Maria A.; Breinlinger, Eric C.; Chien, Ellen Yulin Tsai; Cowart, Marlon D.; Frank, Kristine E.; Friedman, Michael M.; Hardy, David J.; Herold, J. Martin; Liu, Huaqing; Chu, Wei; Scanio, Marc J.; Schrimpf, Michael R.; Vargo, Thomas R.; Van Epps, Stacy A.; Webster, Matthew P.; Little, Andrew J.; Dunstan, Teresa A.; Katcher, Matthew H.; Schedler, David A.; (232 pag.)JP6557436; (2019); B1;,
Pyridine – Wikipedia,
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