With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.609-71-2, name is 2-Oxo-1,2-dihydropyridine-3-carboxylic acid, molecular formula is C6H5NO3, molecular weight is 139.1088, as common compound, the synthetic route is as follows.609-71-2
This compound was prepared according to the procedure of Y. S. Lo (Synthetic Communications, 1989, 553). Bromine (0.77 eq) was added dropwise at 0C to a stirred solution of 50% NAOH (2.4 eq) in water (1 M solution). After 5 min, 50% NAOH (3 eq) followed by solid 2- hydroxynicotinic acid (1 eq) was added to the mixture and the resulting solution was stirred at 50C. After 20 h, a solution prepared by adding bromine (0. 38 eq) to 50% NAOH (1. 2 eq) in water (1 M solution) was added to the reaction mixture and stirring continued for another 24 h at 50C. After that time the reaction mixture was cooled to 0C and acidified to pH 2 with concentrated hydrochloric acid to allow the formation of a solid which was isolated by filtration, washed with warm water/isopropanol (3: 1), then with diethyl ether and dried to afford 5-bromo-2- hydroxynicotinic acid (87%) as an off-white solid. OH (400 MHz; DMSO) 8.25 (1H, d, J 2.7), 8.33 (1H, d, J 2.7), 13.84 (2H, bs) ; BC (400 MHZ ; DMSO) 99.45, 117.97, 142.01, 147.42, 163.22, 163.88 ; M/Z (ES-) 218-216 (M-H)-.
Statistics shows that 609-71-2 is playing an increasingly important role. we look forward to future research findings about 2-Oxo-1,2-dihydropyridine-3-carboxylic acid.
Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA; WO2004/110442; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem