The origin of a common compound about 2-Ethoxy-3-iodopyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 766557-60-2, 2-Ethoxy-3-iodopyridine, other downstream synthetic routes, hurry up and to see.

Application of 766557-60-2, Adding some certain compound to certain chemical reactions, such as: 766557-60-2, name is 2-Ethoxy-3-iodopyridine,molecular formula is C7H8INO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 766557-60-2.

EXAMPLE 1 N-fi-Cyano-i-fP^-dimethoxyphenyQsulphonyll-S-p-ethoxypyridin-S-yO^-oxo^S- dihydro- 1 H-indol-3-yl]-4-(1 -methylpiperidin-4-yl)piperazine- 1 -carboxamide; 1 a) 3-(2-Ethoxypyridin-3-yl)-3-hydroxy-5-iodo- 1, 3-dihydro-2H-indol-2-oneWith ice-bath cooling, 20.86 g (76.40 mmol) of 5-iodoisatin were stirred in 400 ml of anhydrous tetrahydrofuran (THF), and 3.22 g (80.50 mmol, 60% w/w) of sodium hydride were added a little at a time, the temperature being kept between 0-100C. With ice-bath cooling, the suspension was stirred for one hour, during which the pyridine Grignard reagent was prepared. At room temperature, 20 g (80.30 mmol) of the 2-ethoxy-3- iodopyridine were dissolved in 400 ml of anhydrous THF, and over a period of 5-10 minutes 95.6 ml (1 M solution in THF, 95.60 mmol) of ethylmagnesium bromide were added to this solution with cooling, at a temperature between 22 and 15C. The solution was stirred for 20 minutes, during which time the colour changed from colourless to slightly yellowish. The solution of the pyridine Grignard reagents was then, over a period of 5-10 minutes, added to the solution, cooled in an ice-bath, of the 5-iodoisatin sodium salt, the temperature fluctuating between 5 and 18C. After the addition of the Grignard reagent had ended, the ice-bath was removed, and the reaction mixture was stirred at room temperature for another 2 hours. Excess saturated ammonium chloride solution was added, followed by ethyl acetate, and the mixture was stirred for another 5 minutes. The aqueous phase was removed and extracted with ethyl acetate (2 x). The combined organic phases were washed with water (2 x), and the solvent was removed under reduced pressure. Initially, unreacted 5-iodoisatin precipitated from the still dilute solution and was removed, and after further concentration the product, too, crystallized out. The suspension was stored in a refrigerator at 5C for two hours and the slightly yellowish solid was then filtered off and washed with a little ethyl acetate. The desired 3-(2- ethoxypyridin-3-yl)-3-hydroxy-5-iodo-1 ,3-dihydro-2/-/-indol-2-one (17.1 g, 43.16 mmol, 57%) was isolated after drying at 400C.ESI-MS [M+H+] = 397.05 Calculated for Ci5H13IN2O3 = 396.19

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 766557-60-2, 2-Ethoxy-3-iodopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ABBOTT GMBH & CO. KG; WO2008/80970; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem