Synthetic Route of 89364-04-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89364-04-5, name is 3-Bromo-4-nitropyridine, molecular formula is C5H3BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Under a nitrogen stream3-bromo-4-nitropyridine 3.4g (16.9 mmol),5spiro [benzo [c] fluorene-7,9′-fluorene] -5-ylboronic acid, 8.3g (20.2 mmol) 1.0 g (5 mol%) of Pd (PPh3) 4, and potassium carbonate, 7.0 g (50.6 mmol)80 ml / 40 ml / 40 ml of Toluene / H 2 O / Ethanol was added, and the mixture was stirred at 110 C for 3 hours.After completion of the reaction, the organic layer was separated using methylene chloride and water was removed using MgSO4.The solvent of the organic layer was removed, and the residue was purified by column chromatography to give the desired compound B1 (5.9 g, 12.1 mmol, yield 72%).
According to the analysis of related databases, 89364-04-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Doosan Co., Ltd; Kim Hong-seok; Ra Jong-gyu; (52 pag.)KR2019/2183; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem