Application of 75358-90-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 75358-90-6 as follows.
To a nitrogen flushed solution of Description 34 (14.27 g, 81 mmol) and conc. HC1 (15 ml) was added 10% Palladium on carbon (2 g), and the resulting mixture hydrogenated at 50 psi until HPLC and MS indicated complete conversion (approx 2 days). The catalyst was removed by filtration and the filtrate evaporated to give the title compound (17.55 g, 100%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75358-90-6, its application will become more common.
Reference:
Patent; Merck Sharp & Dohme Limited; WO2004/46133; (2004); A1;,
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