Related Products of 1018505-59-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1018505-59-3, name is 5-(4-Ethylpiperazin-1-yl)pyridin-2-amine, molecular formula is C11H18N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of impure 5-(4-ethylpiperazin- 1 -yl)pyridin-2-amine (1.00 g, 4.85′ mmol assumed), 8-bromo-6-chloroimidazo[l ,2-a]pyridine hydrochloride salt (1.30 g, 4.85 mmol), 2,2′-bis(diphenylphosphino)-l,r-binaphthalene (634 mg, 1.02 mmol) and cesium carbonate (4.90 g, 15.0 mmol) in toluene (50 mL) was sparged with nitrogen while stirring for 10 min. Palladium(II) acetate (120 mg, 0.491 mmol) was then added and the reaction stirred at reflux for 18 h. After this time, the reaction was cooled to room temperature, diluted in a mixture of 1 : 1 methanol/methylene chloride (100 mL) and filtered through diatomaceous earth. The filtrate was concentrated under reduced pressure and the resulting residue purified by chromatography (silica, gradient, 1 : 19 methanol/methylene chloride to 1 :6methanol/methylene chloride) to afford 6-chloro-Ar-(5-(4-ethylpiperazin-l-yl)pyiidin-2- yl)imidazo[l,2-a]pyridin-8-amine as a yellow-green solid: NMR (400 MHz, DMS0- )d 9.12 (s, 1H), 8.30 (d, J = 2.0 Hz, 1H), 8.26 (d, J = 2.0 Hz, 1H), 7.99 (d, J = 2.8 Hz, 1 H), 7.89 (d, J = 0.8 Hz, 1H), 7.55 (d, J= 0.8 Hz, 1H), 7.43 (dd, J = 8.8, 2.8 Hz, 1H), 7.35 (d, J= 8.8 Hz, 1H), 3.11-3.10 (m, 4H), 2.50-2.49 (m, 4H, merged with DMSO peak), 2.38-2.37 (m, 2H), 1.04 (t, J= 7.2 Hz, 3H).
According to the analysis of related databases, 1018505-59-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GILEAD SCIENCES, INC.; BLOMGREN, Peter; CURRIE, Kevin, S; KROPF, Jeffrey, E.; LEE, Seung, H.; MITCHELL, Scott, A.; SCHMITT, Aaron, C.; XU, Jianjun; ZHAO, Zhongdong; WO2011/112995; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem