In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1111637-74-1, name is 1-(5-Bromo-2-fluoropyridin-3-yl)ethanone, the common compound, a new synthetic route is introduced below. Product Details of 1111637-74-1
Step 2: 5-bromo-3-methyl-lH-pyrazolo[3,4-b]pyridine To a solution of l-(5-bromo-2-fluoropyridin-3-yl)ethanone (43 g, 197.2 mmol) in ethanol (500 niL) was added hydrazine monohydrate (34.8 g, 591.6 mmol, 85 %) at RT. After addition, the reaction mixture was refluxed overnight. The reaction mixture was cooled to RT and concentrated to dryness in vacuo. The resulting residue was purified by column chromatography (silica gel, 100-200 mesh, 5% to 17% ethyl acetate in petroleum ether) affording 5-bromo-3-methyl-lH-pyrazolo[3,4-b]pyridine (35g, 83.7%): NMR (400 MHz, DMSO-d6): delta 13.42 (s, 1H), 8.51 (m, 2H), 2.54 (s, 3H).
The synthetic route of 1111637-74-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; HUESTIS, Malcolm; KELLAR, Terry; PATEL, Snahel; SHORE, Daniel; SIU, Michael; (260 pag.)WO2016/142310; (2016); A1;,
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