Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 65753-47-1, name is 2-Chloro-3-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. 65753-47-1
EXAMPLE 2Synthesis of Additional Representative Substituted Biaryl Ouinolin-4-ylamine AnaloguesA. 5-Trifluoromethyl-6-[8-(‘5-trifluoromethyl-pyridm-2-ylammo)-pyrido[2,3-&lpyrazin-3-yll- nicotinamide (compound 4) 1. 2-Methoxy-3-trifluoromethyl-pyridine Heat a mixture of 2-chloro-3-trifluoromethyl-pyridine (1.8 g, 10 mmol) and sodium methoxide (4M, 5 mL, 20 mmol) in MeOH (20 mL) at reflux for 18 hours. Cool the mixture and remove the volatiles by rotary evaporation. Dissolve the residue in EtOAc (50 mL) and wash with water (50 mL), saturated NaHCO3(aq) (50 mL) and brine (50 mL). Dry the organic extract overMgSO4 and remove the solvent under reduced pressure to yield the title compound.
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Reference:
Patent; NEUROGEN CORPORATION; WO2006/42289; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem