Electric Literature of 144584-32-7 , The common heterocyclic compound, 144584-32-7, name is 3-Bromo-2,4-dichloropyridine, molecular formula is C5H2BrCl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 96 2-Chloro-3-bromo-4-(cis-4-phenylcyclohexylamino)-pyridine 2.27 g (10 mmol) of 2,4-dichloro-3-bromopyridine, 2.6 g (15 mmol) of cis-4-phenylcyclohexylamine and 0.1 g of ammonium chloride are heated at 120 C. for 10 hours in 10 ml of N-methylpyrrolidone. After cooling, saturated sodium hydrogencarbonate solution is added and the reaction product is extracted with ethyl acetate. Purification is carried out by column chromatography. Yield: 1.9 g (52%); m.p. 105 C. 1 H-NMR (CDCl3): delta: 7.96 (d, 1H), 7.18 to 7.36 (m, 5H), 6.42 (d, 1H), 5.36 (d, 1H), 3.85 (m, 1H), 2.65 (m, 1H), 1.5 to 2.2 (m, 8H) ppm.
The synthetic route of 144584-32-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hoechst Schering AgrEvo GmbH; US5723450; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem