Related Products of 957187-27-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 957187-27-8, name is 8-Bromo-6-chloroimidazo[1,2-a]pyridine, molecular formula is C7H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
b) 8-(benzylthio)-6-chloroimidazo[1,2-a]pyridine A mixture of 8-bromo-6-chloroimidazo[1,2-a]pyridine (2.50 g), benzylmercaptan (1.40 mL), tris(dibenzylideneacetone)dipalladium(0) (248 mg), 1,1′-bis(diphenylphosphino)ferrocene (298 mg), DIPEA (3.8 mL) and toluene (20 mL) was stirred under a nitrogen atmosphere at 100 C. for 2 hr. The reaction mixture was filtered to remove an insoluble material and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (3.01 g). 1H NMR (300 MHz, DMSO-d6) delta 4.47 (2H, s), 7.13 (1H, d, J=1.8 Hz), 7.22-7.39 (3H, m), 7.39-7.47 (2H, m), 7.59 (1H, d, J=1.1 Hz), 7.93 (1H, d, J=1.2 Hz), 8.64 (1H, d, J=1.9 Hz).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 957187-27-8, 8-Bromo-6-chloroimidazo[1,2-a]pyridine.
Reference:
Patent; Takeda Pharmaceutical Company Limited; FUJIMOTO, Jun; LIU, Xin; KURASAWA, Osamu; TAKAGI, Terufumi; CARY, Douglas Robert; BANNO, Hiroshi; ASANO, Yasutomi; KOJIMA, Takuto; (159 pag.)US2019/169166; (2019); A1;,
Pyridine – Wikipedia,
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