Related Products of 1796-84-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1796-84-5 as follows.
Compound 3c (3.0 g, 13.2 mmol), 4-ethoxy-3-nitropyridine (2.7 g, 13.2 mmol) and DIPEA (1.89 g, 14.6 mmol) were dissolved in N-methylpyrrolidinone (5 ml). The reaction mixture was heated to 120 C. for 18 hours. The reaction solution was cooled, extracted with ethyl acetate, washed with water, dried over magnesium sulfate, and concentrated. Then ether was added to precipitate solids, and compound 3d (1.5 g, 33%) was obtained by suction filtration. MS: 347.2 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1796-84-5, its application will become more common.
Reference:
Patent; SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES; LIU, Hong; WU, Beili; ZHENG, Yongtang; XIE, Xin; JIANG, Hualiang; PENG, Panfeng; LUO, Ronghua; LI, Jing; LI, Jian; ZHU, Ya; CHEN, Ying; ZHANG, Haonan; YANG, Liumeng; ZHOU, Yu; CHEN, Kaixian; (94 pag.)US2017/44187; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem