Introduction of a new synthetic route about 5-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1026201-52-4, 5-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid, and friends who are interested can also refer to it.

Related Products of 1026201-52-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1026201-52-4, name is 5-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below.

Step1:tert-Butyl5-bromoimidazo[1,2-a]pyridin-2-ylcarbamate.Toastirredsolutionof5-bromoimidazo[1,2-a]pyridine-2-carboxylicacid(1.00g,4.15mmol,1.0eq.)int-BuOH(20mL)andtoluene(20mL)wasaddedDPPA(1.37g,5.00mmol,1.2eq.)atanice-waterbathtemperature.Et3N(0.70mL,5.00mmol,1.2eq.)wasthenaddeddropwise.Theresultantmixturewasheatedtorefluxfor14hrs.TLCindicatedthedisappearanceof5-bromoimidazo[1,2-a]pyridine-2-carboxylicacid.Thecrudereactionmixturewasconcentratedtodryness.Theresiduewaspurifiedbyacolumnchromatography(200-300meshsilicagel,PE/EA5/1)toaffordtert-butyl5-bromoimidazo[1,2-a]pyridin-2-ylcarbamate.1HNMR(400MHz,DMSO-d6)delta(ppm)10.14(br,1H),7.82(s,1H),7.47(d,J8.7Hz,1H),7.24(d,J6.8Hz,1H),7.16-7.20(m,1H),1.49(s,9H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1026201-52-4, 5-Bromoimidazo[1,2-a]pyridine-2-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; JN THERAPEUTICS; LI, Jin; WU, Shung; YANG, Minmin; CHEN, Sean; HAO, Wenshan; (148 pag.)WO2016/119700; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem