Reference of 77618-99-6 ,Some common heterocyclic compound, 77618-99-6, molecular formula is C6H8N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A. 2-Amino-5-(methylsulfinyl)pyridine A solution of 2-amino-5-(methylthio)pyridine (10.1 g, 50 mmol) and 200 ml of CH2 Cl2 is treated dropwise with 200 ml of CH2 Cl2 containing 85% m-chloroperbenzoic acid (10.15 g, 50 mmol) at 20 C. After the addition is complete, the reaction mixture is stirred an additional 15 minutes and washed with 500 ml of saturated NaHCO3 solution. The organic layer is separated, washed with H2 O, and dried. Evaporation of the solvent in vacuo and recrystallization from EtOH yields the title compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,77618-99-6, its application will become more common.
Reference:
Patent; E. R. Squibb & Sons, Inc.; US4221796; (1980); A;,
Pyridine – Wikipedia,
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