Electric Literature of 3678-62-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3678-62-4, name is 2-Chloro-4-methylpyridine, molecular formula is C6H6ClN, molecular weight is 127.57, as common compound, the synthetic route is as follows.
lOg of 1.-.2-Ghlar6-4-methylpyridine are ”dissolved in 50 ml.’of ‘-CH3CN.’ and- heated to’?? 85C. Then a mixture of 32g -N-“Chlorosuccinimid and l,6g”AIBN is added over a period of 5 minutes. -The resulting- mixture is refluxed . for two?hours,- -then the solvent is removed in vacuo, the residue treated ? with 100ml of CH2C12 ?? and washed with water 2.’times.”The organic phases ‘are collected, dried over Na2S04 and the residue obtained after evaporation of the solvent-is- distilled (80C, 100 mTorr) . Yield 79%
The chemical industry reduces the impact on the environment during synthesis 3678-62-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; AVENTIS PHARMA S.A.; WO2006/10642; (2006); A1;,
Pyridine – Wikipedia,
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