Synthetic Route of 14121-36-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14121-36-9, name is 2,3,4,6-Tetrachloropyridine, molecular formula is C5HCl4N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1: 100g of tetrachloropyridine, 0.5g of catalyst, 15g of acid binding agent,3g of auxiliary agent and 500g of organic solvent are placed in a 1L autoclave, and the autoclave is evacuated three times until the autoclave is in a vacuum state;The tetrachloropyridine is 2,3,4,6-tetrachloropyridine;The catalyst includes a supported activated carbon, a metal M1, a metal M2, and a metal M3 supported on the supported activated carbon,The metal M1 is Pd, the metal M2 is Ag, and the metal M3 is V,The mass percentage content of metal M1 in the catalyst is 2%, and the mass percentage content of metal M2 is 0.4%.The mass percentage of metal M3 is 0.15%; The acid binding agent is triethylamine and urea, and the mass ratio of the triethylamine and urea is 1: 1;The auxiliary is citric acid;The organic solvent is ethyl acetate; Step 2: Replace the high-pressure reactor after vacuuming in Step 1 with nitrogen for three times, and then replace with hydrogen for three times;Step three, continue to introduce hydrogen into the autoclave after the hydrogen replacement in step two, control the hydrogen pressure to 1.0 MPa, the temperature to 50 C., and react for 7 hours under the stirring condition, and reduce to room temperature;Step 4: Drain the hydrogen in the autoclave after the temperature drops to room temperature in Step 3, replace it with nitrogen for three times, filter the system in the autoclave to obtain the filtrate and the recovered catalyst, and reuse the recovered catalyst; Step 5. Distillate the filtrate in step 4 under reduced pressure to obtain 2,3-dichloropyridine as a white solid.The solvent obtained by vacuum distillation is recovered and reused; the vacuum of the vacuum distillation is -0.092 MPaThe temperature of the vacuum distillation was 40 C. The yield of 2,3-dichloropyridine was 98.1%, and the purity was 99.3%.
According to the analysis of related databases, 14121-36-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Xi’an Kaili New Materials Co., Ltd.; Li Xiaoan; Xiao Dawei; Han Bin; Zhang Yu; Zhang Zhixiang; Zeng Yongkang; Wan Kerou; Gao Wu; (13 pag.)CN110759859; (2020); A;,
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