Adding a certain compound to certain chemical reactions, such as: 56673-34-8, 3-Bromo-6-mercaptopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Bromo-6-mercaptopyridine, blongs to pyridine-derivatives compound. name: 3-Bromo-6-mercaptopyridine
Powdered sodium methoxide (1.08 g, 19.95 mmol) and 1-bromo-3-chloropropane (2.87 mL, 28.7 mmol) were added to a stirred suspension of 5-bromopyridine-2-thiol (3.16 g, 16.63 mmol) in anhydrous methanol (80 mL). The mixture was heated at 60C and stirred under N2 for 1.5 h. After cooling to room temperature, the mixture wasquenched with water-brine (1:1, 100 mL) and extracted with EtOAc (2 x 100 mL). The combined organic fraction was washed with brine (50 mL), then dried (MgSO4) and reduced in vacuo, to give the title compound (3.92 g, 88%) as a yellow solid. H (500 MHz, CDC13) 8.50-8.44 (m, 1H), 7.58 (dd,J8.5, 2.4 Hz, 1H), 7.07 (dd,J8.5, 0.6 Hz, 1H), 3.67 (t,J6.4 Hz, 2H), 3.29 (t,J6.9 Hz, 2H), 2.17 (p,J6.6 Hz, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,56673-34-8, 3-Bromo-6-mercaptopyridine, and friends who are interested can also refer to it.
Reference:
Patent; UCB BIOPHARMA SPRL; ALEXANDER, Rikki Peter; BENTLEY, Jonathan Mark; BRACE, Gareth Neil; BROOKINGS, Daniel Christopher; CHOVATIA, Praful Tulshi; DEBOVES, Herve Jean Claude; JOHNSTONE, Craig; JONES, Elizabeth Pearl; KROEPLIEN, Boris; LECOMTE, Fabien Claude; MADDEN, James; MILLER, Craig Adrian; PORTER, John Robert; SELBY, Matthew Duncan; SHAW, Michael Alan; VAIDYA, Darshan Gunvant; YULE, Ian Andrew; WO2015/86506; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem