Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109306-86-7, name is 2-(2-Bromophenyl)pyridine. A new synthetic method of this compound is introduced below., Formula: C11H8BrN
To a solution of 2-(2-bromophenyl)pyridine (0.48 g, 2 mmol) in THF (10 mL) cooled with a dry ice-acetone bath was added dropwise a solution of n-BuLi in hexanes (1.3 mL, 1.6 M, 2.08 mmol, Aldrich) via a syringe. After the reaction mixture was stirred at -78 C. for 30 min, a solution of ZnCl2 in ether (2 mL, 1.0 M, 2 mmol, Aldrich) was added slowly via a syringe. The cooling bath was removed and the reaction mixture was warmed to ca 0 C. to room temperature. The bromide-bridged dimer [Ir(ppy)2Br]2 (0.58 g, 0.5 mmol) was added to the reaction mixture in one portion and the mixture was stirred for 30 min. Dichloromethane (10 mL) was added to accelerate the reaction. After stirring for ca. 1 hour at room temperature, the mixture was transferred into a one-necked flask and remaining yellow precipitates were washed into the flask with dichloromethane. The solvent was evaporated and the residue was dissolved in dichloromethane and purified by flash chromatography on silica gel with dichloromethane. The product was obtained as isomerically pure mer-(ppy)3Ir, 0.51 g, 78%.
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Reference:
Patent; Eastman Kodak Company; US6835835; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem