Reference of 58483-98-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58483-98-0, name is 2-Amino-5-bromonicotinamide, molecular formula is C6H6BrN3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2-amino-5-bromonicotinamide (100 mg, 0.46 mmol), 3- fluorobenzaldehyde (69 mg, 0.56 mmol), NaHSC>3 (40 mg, 0.38 mmol), 4-methylbenzene sulfonic acid (15 mg, 0.05 mmol) in DMAc (3 mL) was stirred at 115C for 1.5 h, then additional NaHSC>3 (40 mg, 0.38 mmol) was added to the mixture. After 1.5 h, the third portion of NaHSC>3 (40 mg, 0.38 mmol) was added to the mixture. After being stirred overnight at 115C, the reaction mixture was concentrated in vacuo, suspended in water and filtered to give the product of 6-bromo-2-(3-fluorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one (70 mg, yield: 47%), which was used for the next step without further purification. XH-NMR (DMSO-i, 400 MHz) delta 13.04 (br s, 1H), 9.07 (d, J= 2.8 Hz, 1H), 8.65 (d, J= 2.8 Hz, 1H), 8.08 (d, J= 8.0 Hz, 1H), 8.02 (dd, J= 9.6, 1.6 Hz, 1H), 7.60-7.68 (m, 1H), 7.45-7.54 (m, 1H). MS (M+H)+: 320/322.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 58483-98-0, 2-Amino-5-bromonicotinamide.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); A1;,
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