Synthetic Route of 61494-55-1, Adding some certain compound to certain chemical reactions, such as: 61494-55-1, name is 2-(2-Chloropyridin-3-yl)acetic acid,molecular formula is C7H6ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61494-55-1.
PREPARATIVE EXAMPLE 1 STR50 A stirred mixture of 5 grams(g) (0.029 mole) of 2-chloro-3-pyridineacetic acid, 9.4 g (0.058 mole) of 3-trifluoromethylaniline and 50 mg of p-toluenesulfonic acid in 15 mL of n-pentanol is heated for 24 hours from 130 to 140 C. After the solvent is removed at reduced pressure, the resulting solid residue is triturated with water, filtered, and recrystallized from isopropylacetate to afford 6 g of pure product of Formula A with melting point 133-134 C. (75% yield). By essentially the same method using aniline, 1,3-dihydro-1-phenyl-2H-pyrrolo[2,3-b]pyridine-2-one is prepared, m.p. 120-121 C.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 61494-55-1, 2-(2-Chloropyridin-3-yl)acetic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Schering Corporation; US5023265; (1991); A;,
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