1003-68-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1003-68-5, name is 5-Methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.
To a 25 mL round bottom flask was added 0.10 g (1 mmol, 1 quiv.) Of compound 3,0.17 g (1 mmol, 1 quiv.) Bromobenzene, 1.4 g (10 mmol, 10 equiv.) K2CO3,0.05 g (0.26 mmol, 0.25 equiv.) CuI,5 mL of DMF as solvent,Reflux stirring reaction 1h,TLC followed by reaction completion, cooling, adding 30 mL of water, 3 x 20 mL of ethyl acetate extraction, and an organic layer of anhydrous sulfuric acidSodium dry, spin dry, 300 mesh silica gel column chromatography, eluent petroleum ether: ethyl acetate = 1: 3 (v / v) to give pirfenidone,The yield was 76%.
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Reference:
Patent; Sichuan Univeristy; Yi, Shufan; Li, Yong; Cao, Tingting; Yang, Ziyao; (17 pag.)CN106083702; (2016); A;,
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