Reference of 109306-86-7 , The common heterocyclic compound, 109306-86-7, name is 2-(2-Bromophenyl)pyridine, molecular formula is C11H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2- (2-bromophenyl) pyridine(40.7 g, 174.0 mmol) was dissolved in 500 ml of anhydrous THF and cooled to -78 C. 2.5 M n-BuLi (73.2 ml, 183 mmol) was slowly added thereto and stirred for 1 hour.To this reaction solution was added 9-chloro-11H-benzo [b] fluoreno [2,3-e] [1,4] dioxin-11-one (53.0 g, 165.4 mmol) obtained in the above Step 3 The temperature was then slowly raised to room temperature and stirred for 3 hours.Aqueous ammonium chloride solution was added to terminate the reaction, distilled water was added thereto, and the organic layer was extracted with ethyl acetate. The obtained organic layer was dried over Na2SO4, distilled under reduced pressure and then purified by column chromatography to obtain the compound 9-chloro-11- (2- (pyridin-2-yl) phenyl) -11H-indeno [ Benzo [b, e] [1,4] dioxin-11-ol (69.6 g, yield 80%).
The synthetic route of 109306-86-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Doosan Co., Ltd; Choi Tae-jin; Kim Yeong-bae; Kim Hoe-mun; (65 pag.)KR2019/30391; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem