Adding a certain compound to certain chemical reactions, such as: 127446-34-8, N-(6-Chloro-3-formylpyridin-2-yl)pivalamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 127446-34-8, blongs to pyridine-derivatives compound. Formula: C11H13ClN2O2
An oven-dried flask was charged with THF (80 mL) anddiisopropylamine (8.2 mL, 58.4 mmol). The solution was cooled to -78C then n-butyllithium (2.5 M solution in hexane, 23.3 mL, 58.3 mmol)was added. The mixture was stirred for 15 mm then a solution of tertbutyl acetate (7.8 mL, 58.3 mmol) in THF (2 mL) was added. Afterstirring at -78C for 20 mm a solution of N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropanamide (6.7 g, 27.8 mmol) in THF (5 mL) was added. The mixture was allowed to warm to room temperature then was poured into sat. NH4CI. The resulting mixture was extracted with ethyl acetate and the organic phase was dried and evaporated in vacuo toobtain the title compound (9.4 g, 26.4 mmol, 95% yield). LC-MS (M-H) = 357.3
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,127446-34-8, its application will become more common.
Reference:
Patent; AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.; OMBRATO, Rosella; MAGARO’, Gabriele; GAROFALO, Barbara; FURLOTTI, Guido; MANGANO, Giorgina; CAPEZZONE DE JOANNON, Alessandra; (182 pag.)WO2017/211759; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem