108-48-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 108-48-5, name is 2,6-Dimethylpyridine, molecular formula is C7H9N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a 250 mL flask, 2,6-lutidine (5 mL, 43 mmol), NBS (N-bromosuccinimide) (7.65 g, 43 mmol) and CCl4 (75 mL) were sequentially added and the mixture was heated under reflux in an oil bath.To the above reflux solution was added AIBN (azobisisobutyronitrile) (0.125g / time, once every 1h, plus 7 times), the reaction was filtered off to remove the white succinimide precipitation,The filtrate was stripped to remove the solvent to give a tan oil, which was isolated as a pink oil (5.4 g, 68%) by column chromatography using CH2Cl2 as eluent.
The chemical industry reduces the impact on the environment during synthesis 108-48-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Northwest University; Zhang Ronglan; Yang Weixing; Su Yuanyuan; Zhao Jianshe; (16 pag.)CN107312024; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem