Adding a certain compound to certain chemical reactions, such as: 79055-63-3, 2-Chloro-6-methylpyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 79055-63-3, blongs to pyridine-derivatives compound. SDS of cas: 79055-63-3
Lithium bis(trimethylsilyl)amide in THF (4.23 mL, 1 M, 4.23 mmol) was added to a solution of ethyl 4-[(3,3-difluoro-l-methyl-cyclobutyl)sulfamoyl]-3-fluoro-l -methyl-pyrrole -2-carboxylate (500 mg, 1.41 mmol) and 2-chloro-6-methyl-pyridin-4-amine (316 mg, 1.76 mmol) in THF (7.6 mL) and the mixture was stirred for 2 hours at room temperature. The mixture was quenched with NH4C1 solution, diluted with brine and extracted with EtOAc (25mL). The combined extracts were dried on Na2S04, filtered and concentrated in vacuo. The residue was purified by column chromatography using a gradient from 10 till 100% EtOAc in heptane. The product fractions were concentrated. The residue was crystallised out of isopropanol, the crystals were collected on a filter and dried overnight in vacuo at 50C, resulting in compound (0650) 130 (378 mg) as a white powder. Method B: Rt: 1.08 min. m/z: 449.1 (M-H)~ Exact mass: 450.1. DSC: From 30 to 300 C at 10C/min, peak 217.7 C. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.42 (s, 3 H), 2.42 (s, 3 H), 2.52 – 2.63 (m, 2 H), 2.79 – 2.99 (m, 2 H), 3.81 (s, 3 H), 7.47 – 7.51 (m, 1 H), 7.56 (d, J=4.6 Hz, 1 H), 7.60 – 7.64 (m, 1 H), 8.24 (s, 1 H), 10.45 (s, 1 H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,79055-63-3, its application will become more common.
Reference:
Patent; JANSSEN SCIENCES IRELAND UC; VANDYCK, Koen; HACHE, Geerwin Yvonne Paul; LAST, Stefaan Julien; ROMBOUTS, Geert; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard; WO2015/118057; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem