Adding a certain compound to certain chemical reactions, such as: 14916-65-5, 6-Nitropyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 14916-65-5, blongs to pyridine-derivatives compound. SDS of cas: 14916-65-5
Dichloromethane 10 ml, 2-nitro 5-aminopyridine (200 mg, 1.4 mmol) starting material 1 and ethyl 4-bromo-2-oxo-butyrate (280 ml, 1.4 mmol) were added to a 50 ml reaction flask at room temperature. The magnetic stirring reaction was performed for 1 to 2 hours, and the solvent was concentrated under reduced pressure. The residue was dissolved with 10 ml of ethanol and specifically ethanol, and the mixture was heated under reflux for 3 h. The reaction was completely checked by TLC.The reaction solution was allowed to cool to room temperature and concentrated under reduced pressure to remove the ethanol.The residue was washed with saturated sodium hydrogencarbonate solution and the aqueous layer was extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate overnight, suction filtered and concentrated, and the residue was separated using silica gel column chromatography to give Intermediate 2 as a yellow solid.MS calculated 235, found 236 [M+l].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,14916-65-5, 6-Nitropyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; Wuxi Fuqi Pharmaceutical Co., Ltd.; Wang Tao; Wang Binbin; Wang Qinglin; Sun Yilin; You Benjia; Cao Na; (9 pag.)CN107573364; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem