A new synthetic route of 823-39-2

The synthetic route of 823-39-2 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 823-39-2, name is 3,4-Dimethylpyridin-2-amine, the common compound, a new synthetic route is introduced below. Safety of 3,4-Dimethylpyridin-2-amine

Then the solid was stirred with 100 ml ethyl acetate, 150 ml ethanol and 10 ml half concentrated hydrochloric acid. The solvent volume was reduced in vacuo and the precipitate recovered by filtration, washed with diethyl ether and dried over phosphorous pentoxide. 4.97 g (0.021 Mol, 63%) of product was obtained as a white powder. 1H NMR (dDMSO): delta 6.95 ppm (s, 1H), delta 8.02 ppm (s, 1H), delta 8.67 ppm (s, 1H). To prepare 7-butyryloxy-3-carboxy-6-chlorocoumarin, 3.1 g (12.9 mMol) 3-carboxy-6-chloro-7-hydroxycoumarin were dissolved in 100 ml dioxane and treated with 5 ml butyric anhydride, 8 ml pyridine and 20 mg dimethyl aminopyridine at room temperature for two hours. The reaction solution was added with stirring to 300 ml heptane upon which a white precipitate formed. It was recovered by filtration and dissolved in 150 ml ethyl acetate. Undissolved material was removed by filtration and the filtrate extracted twice with 50 ml 1 N hydrochloric acid/brine (1:1) and then brine. The solution was dried over anhydrous sodium sulfate. Evaporation in vacuo yielded 2.63 g (8.47 mMol, 66%) of product. 1H NMR (CDCl3): delta 1.08 ppm (t, 3H, J=7.4 Hz, butyric methyl), delta 1.85 ppm (m, 2H, J1 delta J2=7.4 Hz, butyric methylene), delta 2.68 ppm (t, 2H, J=7.4 Hz, butyric methylene), delta 7.37 ppm (s, 1H, coumarin), delta 7.84 ppm (s, 1H, coumarin), delta 8.86 ppm (s, 1H, coumarin). Preparation of 7-butyryloxy-3-benzyloxycarbonylmethylaminocarbonyl-6-chlorocoumarin is effected as follows.

The synthetic route of 823-39-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Invitrogen Corporation, a Delaware corporation; US2006/8855; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem