Adding a certain compound to certain chemical reactions, such as: 700811-29-6, 2-Chloro-4-hydrazinopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Chloro-4-hydrazinopyridine, blongs to pyridine-derivatives compound. Safety of 2-Chloro-4-hydrazinopyridine
A microwave reaction vessel was charged with 500 mg of (2-chloro- pyridin-4-yl) -hydrazine (3.48 mmol, 1. 3 equiv) and 848 mg g of N-cyano-N’-(2-phenyl- ISOUREIDO)-BENZENESULFONAMIDE (2.68 mmol, 1 equiv) in a mixture of NMP (5 mL) and diisopropylethylamine (1.4 mL). The sealed vessel was warmed to 220 C for 6 min via microwave irradiation. Upon cooling, the resulting solution was poured onto saturated aqueous sodium hydrogen carbonate (40 mL) and a yellow solid precipitated. The precipitate was collected by vacuum filtration and washed with water (3 X 10 ML). AFTER azeotropic drying (3 x 50 mL of acetonitrile) the dark yellow solid was used without further purification (723.1 mg, 74%); 1H NMR (400 MHz, (CD3) 2SO) 8 9.67 (1H, s), 8. 45 (1H, d, J= 6.3). 7.69 (6H, m), 7.12 (4H, br s); MS (ES) mle 366. 38, (ES) mle 364.49
At the same time, in my other blogs, there are other synthetic methods of this type of compound,700811-29-6, 2-Chloro-4-hydrazinopyridine, and friends who are interested can also refer to it.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; LEDEBOER, Mark W.; DAVIES, Robert J.; WO2005/13982; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem