115473-15-9 , The common heterocyclic compound, 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, molecular formula is C7H10ClNOS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 5: Methyl(S)-2(2-chlorophenyl)-2-(2,4,5,6,7,7a-hexahydrothieno [3,2-c]-5- pyridin-2-one)acetate[0064] In a dry, 250-ml reaction flask, 5.94 gm (31.1 mmoles) of 5,6,7, 7a-tetrahydro-4H- thieno[3,2-c]pyridin-2-one hydrochloride, 39 ml of dichloromethane and 29.8 g of a 30% aqueous solution of potassium carbonate were mixed. After stirring for 10 minutes, 10 gm of (25.9 mmoles of Methyl (R)-2- (4-nitrophenylsulfonyloxy)-2(2-chlorophenyl)acetate as a solution in 13 ml of dichloromethane was added. The two-phase medium thus obtained was heated under reflux for 6 hrs. Then cooled to about 30C. Filtered the R.M. Filtrate was having two layers. MDC layer was washed with brine solution. Dried over anhydrous sodium sulfate. After concentration Methyl(S)-2(2-chlorophenyl)-2- (2,4,5,6,7,7a-hexhydrothieno[3,2-c]-5-pyridin-2-one)acetate [(S)-thiolactone of Formula II ] was obtained.
According to the analysis of related databases, 115473-15-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; IPCA LABORATORIES LIMITED; KUMAR, Ashok; NELLITHANATH, Thankachen, Byju; WO2012/25942; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem