As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17322-91-7, name is 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one, molecular formula is C7H6N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one
5-hydroxy -1H- pyrrolo [3,2] pyridine (10 mmol)Soluble in 40 ml of dichloromethane solution,Add 10 ml of triethylamine to it,Control temperature below 10 C,Add to the systema solution of 2-chloroacetyl chloride (12 mmol) in dichloromethane,After the addition is completed, return to room temperature.Stir at room temperature for 10 hours,The reaction system was then washed with 50 ml of a 5% aqueous solution of sodium carbonate.The organic phase is dried over anhydrous Na2SO4.After evaporating the solvent,The obtained solid is separated by flash column chromatography,Get 1.9 g light yellow2-Chloro-1-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-ethanone solid,The yield was 90%.
With the rapid development of chemical substances, we look forward to future research findings about 17322-91-7.
Reference:
Patent; Sang Qi; (10 pag.)CN108218865; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem