Electric Literature of 131747-41-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131747-41-6, name is 2-(Trifluoromethyl)isonicotinic acid. A new synthetic method of this compound is introduced below.
A solution of 616 2-(trifluoromethyl)isonicotinic acid (10.0 g, 52.4 mmol) in 20 tetrahydrofuran (150mL) was cooled to 0 C., 1 mol/L 617 borane-tetrahydrofuran solution (105 mL, 105 mmol) was addedunder a nitrogen atmosphere and the mixture was stirred at 75 C. for 2 hr. The reaction mixture was pouredinto ice water, and extracted with ethyl acetate. The organic layer was washed with saturated brine, and driedover sodium sulfate. The desiccant was filtered off, and the filtrate was concentrated under reduced pressureand the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the618 title compound ( 5.60 g , 31.6 mmol, 60%). MS (ESI) m/z 178 (M+H)+ 1H NMR (300 MHz, CDCl3): delta 8.68 (d, J=4.8 Hz, 1H), 7.79 (s, 1H), 7.64 (d, J=4.8 Hz, 1H) . 5.62 (br-s,1H), 4.66 (s, 2H),
At the same time, in my other blogs, there are other synthetic methods of this type of compound,131747-41-6, 2-(Trifluoromethyl)isonicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; EA PHARMA CO., LTD.; KOBAYASHI, Kaori; SUZUKI, Tamotsu; KAWAHIRA, Mizuki; FUJII, Tomohiro; SUGIKI, Masayuki; OHSUMI, Koji; OKUZUMI, Tatsuya; (285 pag.)US2016/332999; (2016); A1;,
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