Adding a certain compound to certain chemical reactions, such as: 135124-71-9, 5-(Hydroxymethyl)nicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 5-(Hydroxymethyl)nicotinonitrile, blongs to pyridine-derivatives compound. Safety of 5-(Hydroxymethyl)nicotinonitrile
Compound I-2-3 (2.0 g, 14.91 mmol) was added to a 50 mL single-mouth bottle.Add thionyl chloride (6.5mL),After dichloromethane (20 mL) was reacted at room temperature for 3 h,The reaction was completed by TLC, the reaction system was spun dry, and the oil pump was dried to obtain compound I-2-4.The yield was 1.8 g, and the yield was 79.4%.
The synthetic route of 135124-71-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangzhou Dankang Pharmaceutical Biological Co., Ltd.; Xu Yong; Lin Dang; Huang Lu; Hu Hai; (36 pag.)CN110092779; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem