Reference of 90993-26-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.90993-26-3, name is 7-Bromo-1H-imidazo[4,5-c]pyridine, molecular formula is C6H4BrN3, molecular weight is 198.02, as common compound, the synthetic route is as follows.
Step 2: 7-bromo-lH-imidazo[4,5-c]pyridine 5-oxide To a stirred solution of 7-bromo-lH-imidazo[4,5-c]pyridine (1.0 g, 5.05 mol) and chloroform (20 mL) was added m-chloroperoxybenzoic acid (2.83 g, 12.6 mmol) and the reaction mixture stirred for 30 min at RT. The reaction mixture was filtered, washed with chloroform (10 mL), and the white solid was dried under high vacuum. The solid resulting solid was dissolved in a dichloromethane and methanol mixture, absorbed onto celite and purified by column chromatography (silica gel, 100-200 mesh, 0 to 20% methanol in dichloromethane with 3% triethylamine) affording 7-bromo-lH- imidazo[4,5-c]pyridine 5-oxide as a white solid (580 mg, 54%) used as is in the next step.
Statistics shows that 90993-26-3 is playing an increasingly important role. we look forward to future research findings about 7-Bromo-1H-imidazo[4,5-c]pyridine.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; HUESTIS, Malcolm; KELLAR, Terry; PATEL, Snahel; SHORE, Daniel; SIU, Michael; (260 pag.)WO2016/142310; (2016); A1;,
Pyridine – Wikipedia,
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